Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

An autoimmune stem-like CD8 T cell population drives type 1 diabetes.

Gearty, Sofia V; Dündar, Friederike; Zumbo, Paul; Espinosa-Carrasco, Gabriel; Shakiba, Mojdeh; Sanchez-Rivera, Francisco J; Socci, Nicholas D; Trivedi, Prerak; Lowe, Scott W; Lauer, Peter; Mohibullah, Neeman; Viale, Agnes; DiLorenzo, Teresa P; Betel, Doron; Schietinger, Andrea.

Nature ; 602(7895): 156-161, 2022 02.

Artigo em Inglês | MEDLINE | ID: mdl-34847567

2.

Ovarian cancer mutational processes drive site-specific immune evasion.

Vázquez-García, Ignacio; Uhlitz, Florian; Ceglia, Nicholas; Lim, Jamie L P; Wu, Michelle; Mohibullah, Neeman; Niyazov, Juliana; Ruiz, Arvin Eric B; Boehm, Kevin M; Bojilova, Viktoria; Fong, Christopher J; Funnell, Tyler; Grewal, Diljot; Havasov, Eliyahu; Leung, Samantha; Pasha, Arfath; Patel, Druv M; Pourmaleki, Maryam; Rusk, Nicole; Shi, Hongyu; Vanguri, Rami; Williams, Marc J; Zhang, Allen W; Broach, Vance; Chi, Dennis S; Da Cruz Paula, Arnaud; Gardner, Ginger J; Kim, Sarah H; Lennon, Matthew; Long Roche, Kara; Sonoda, Yukio; Zivanovic, Oliver; Kundra, Ritika; Viale, Agnes; Derakhshan, Fatemeh N; Geneslaw, Luke; Issa Bhaloo, Shirin; Maroldi, Ana; Nunez, Rahelly; Pareja, Fresia; Stylianou, Anthe; Vahdatinia, Mahsa; Bykov, Yonina; Grisham, Rachel N; Liu, Ying L; Lakhman, Yulia; Nikolovski, Ines; Kelly, Daniel; Gao, Jianjiong; Schietinger, Andrea.

Nature ; 612(7941): 778-786, 2022 12.

Artigo em Inglês | MEDLINE | ID: mdl-36517593

3.

Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis.

Schietinger, Andrea; Philip, Mary; Krisnawan, Varintra E; Chiu, Edison Y; Delrow, Jeffrey J; Basom, Ryan S; Lauer, Peter; Brockstedt, Dirk G; Knoblaugh, Sue E; Hämmerling, Günter J; Schell, Todd D; Garbi, Natalio; Greenberg, Philip D.

Immunity ; 45(2): 389-401, 2016 08 16.

Artigo em Inglês | MEDLINE | ID: mdl-27521269

4.

TOX is a critical regulator of tumour-specific T cell differentiation.

Scott, Andrew C; Dündar, Friederike; Zumbo, Paul; Chandran, Smita S; Klebanoff, Christopher A; Shakiba, Mojdeh; Trivedi, Prerak; Menocal, Laura; Appleby, Heather; Camara, Steven; Zamarin, Dmitriy; Walther, Tyler; Snyder, Alexandra; Femia, Matthew R; Comen, Elizabeth A; Wen, Hannah Y; Hellmann, Matthew D; Anandasabapathy, Niroshana; Liu, Yong; Altorki, Nasser K; Lauer, Peter; Levy, Olivier; Glickman, Michael S; Kaye, Jonathan; Betel, Doron; Philip, Mary; Schietinger, Andrea.

Nature ; 571(7764): 270-274, 2019 07.

Artigo em Inglês | MEDLINE | ID: mdl-31207604

5.

A replicating LCMV-based vaccine for the treatment of solid tumors.

Purde, Mette-Triin; Cupovic, Jovana; Palmowski, Yannick A; Makky, Ahmad; Schmidt, Sarah; Rochwarger, Alexander; Hartmann, Fabienne; Stemeseder, Felix; Lercher, Alexander; Abdou, Marie-Therese; Bomze, David; Besse, Lenka; Berner, Fiamma; Tüting, Thomas; Hölzel, Michael; Bergthaler, Andreas; Kochanek, Stefan; Ludewig, Burkhard; Lauterbach, Henning; Orlinger, Klaus K; Bald, Tobias; Schietinger, Andrea; Schürch, Christian; Ring, Sandra S; Flatz, Lukas.

Mol Ther ; 32(2): 426-439, 2024 Feb 07.

Artigo em Inglês | MEDLINE | ID: mdl-38058126

6.

Chromatin states define tumour-specific T cell dysfunction and reprogramming.

Philip, Mary; Fairchild, Lauren; Sun, Liping; Horste, Ellen L; Camara, Steven; Shakiba, Mojdeh; Scott, Andrew C; Viale, Agnes; Lauer, Peter; Merghoub, Taha; Hellmann, Matthew D; Wolchok, Jedd D; Leslie, Christina S; Schietinger, Andrea.

Nature ; 545(7655): 452-456, 2017 05 25.

Artigo em Inglês | MEDLINE | ID: mdl-28514453

7.

Turbocharging the T Cell to Fight Cancer.

Schietinger, Andrea.

N Engl J Med ; 386(24): 2334-2336, 2022 06 16.

Artigo em Inglês | MEDLINE | ID: mdl-35648702

8.

Beyond Genomics: Multidimensional Analysis of Cancer Therapy Resistance.

Philip, Mary; Schietinger, Andrea.

Trends Immunol ; 36(11): 665-667, 2015 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-26440701

9.

Tolerance and exhaustion: defining mechanisms of T cell dysfunction.

Schietinger, Andrea; Greenberg, Philip D.

Trends Immunol ; 35(2): 51-60, 2014 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-24210163

10.

IL-15 in tumor microenvironment causes rejection of large established tumors by T cells in a noncognate T cell receptor-dependent manner.

Liu, Rebecca Berlant; Engels, Boris; Schreiber, Karin; Ciszewski, Cezary; Schietinger, Andrea; Schreiber, Hans; Jabri, Bana.

Proc Natl Acad Sci U S A ; 110(20): 8158-63, 2013 May 14.

Artigo em Inglês | MEDLINE | ID: mdl-23637340

11.

Cell-intrinsic abrogation of TGF-ß signaling delays but does not prevent dysfunction of self/tumor-specific CD8 T cells in a murine model of autochthonous prostate cancer.

Chou, Cassie K; Schietinger, Andrea; Liggitt, H Denny; Tan, Xiaoxia; Funk, Sarah; Freeman, Gordon J; Ratliff, Timothy L; Greenberg, Norman M; Greenberg, Philip D.

J Immunol ; 189(8): 3936-46, 2012 Oct 15.

Artigo em Inglês | MEDLINE | ID: mdl-22984076

12.

Induced sensitization of tumor stroma leads to eradication of established cancer by T cells.

Zhang, Bin; Bowerman, Natalie A; Salama, Joseph K; Schmidt, Hank; Spiotto, Michael T; Schietinger, Andrea; Yu, Ping; Fu, Yang-Xin; Weichselbaum, Ralph R; Rowley, Donald A; Kranz, David M; Schreiber, Hans.

J Exp Med ; 204(1): 49-55, 2007 Jan 22.

Artigo em Inglês | MEDLINE | ID: mdl-17210731

13.

Antibody recognition of a unique tumor-specific glycopeptide antigen.

Brooks, Cory L; Schietinger, Andrea; Borisova, Svetlana N; Kufer, Peter; Okon, Mark; Hirama, Tomoko; Mackenzie, C Roger; Wang, Lai-Xi; Schreiber, Hans; Evans, Stephen V.

Proc Natl Acad Sci U S A ; 107(22): 10056-61, 2010 Jun 01.

Artigo em Inglês | MEDLINE | ID: mdl-20479270

14.

Intratumoral immune triads are required for adoptive T cell therapy-mediated elimination of solid tumors.

Espinosa-Carrasco, Gabriel; Scrivo, Aurora; Zumbo, Paul; Dave, Asim; Betel, Doron; Hellmann, Matthew; Burt, Bryan M; Lee, Hyun-Sung; Schietinger, Andrea.

bioRxiv ; 2023 Jul 03.

Artigo em Inglês | MEDLINE | ID: mdl-37461721

15.

GABA Regulates Electrical Activity and Tumor Initiation in Melanoma.

Tagore, Mohita; Hergenreder, Emiliano; Perlee, Sarah C; Cruz, Nelly M; Menocal, Laura; Suresh, Shruthy; Chan, Eric; Baron, Maayan; Melendez, Stephanie; Dave, Asim; Chatila, Walid K; Nsengimana, Jeremie; Koche, Richard P; Hollmann, Travis J; Ideker, Trey; Studer, Lorenz; Schietinger, Andrea; White, Richard M.

Cancer Discov ; 13(10): 2270-2291, 2023 Oct 05.

Artigo em Inglês | MEDLINE | ID: mdl-37553760

16.

CD8⁺ T cell differentiation and dysfunction in cancer.

Philip, Mary; Schietinger, Andrea.

Nat Rev Immunol ; 22(4): 209-223, 2022 04.

Artigo em Inglês | MEDLINE | ID: mdl-34253904

17.

Noninvasive Imaging of CD4+ T Cells in Humanized Mice.

Nagle, Veronica L; Hertz, Charli Ann J; Henry, Kelly E; Graham, Maya S; Campos, Carl; Pillarsetty, Nagavarakishore; Schietinger, Andrea; Mellinghoff, Ingo K; Lewis, Jason S.

Mol Cancer Ther ; 21(4): 658-666, 2022 04 01.

Artigo em Inglês | MEDLINE | ID: mdl-35131877

18.

Ketohexokinase-mediated fructose metabolism is lost in hepatocellular carcinoma and can be leveraged for metabolic imaging.

Tee, Sui Seng; Kim, Nathaniel; Cullen, Quinlan; Eskandari, Roozbeh; Mamakhanyan, Arsen; Srouji, Rami M; Chirayil, Rachel; Jeong, Sangmoo; Shakiba, Mojdeh; Kastenhuber, Edward R; Chen, Shuibing; Sigel, Carlie; Lowe, Scott W; Jarnagin, William R; Thompson, Craig B; Schietinger, Andrea; Keshari, Kayvan R.

Sci Adv ; 8(14): eabm7985, 2022 Apr 08.

Artigo em Inglês | MEDLINE | ID: mdl-35385296

19.

TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion.

Shakiba, Mojdeh; Zumbo, Paul; Espinosa-Carrasco, Gabriel; Menocal, Laura; Dündar, Friederike; Carson, Sandra E; Bruno, Emmanuel M; Sanchez-Rivera, Francisco J; Lowe, Scott W; Camara, Steven; Koche, Richard P; Reuter, Vincent P; Socci, Nicholas D; Whitlock, Benjamin; Tamzalit, Fella; Huse, Morgan; Hellmann, Matthew D; Wells, Daniel K; Defranoux, Nadine A; Betel, Doron; Philip, Mary; Schietinger, Andrea.

J Exp Med ; 219(2)2022 02 07.

Artigo em Inglês | MEDLINE | ID: mdl-34935874

20.

Tumor MHC Class I Expression Associates with Intralesional IL2 Response in Melanoma.

Pourmaleki, Maryam; Jones, Caitlin J; Ariyan, Charlotte E; Zeng, Zheng; Pirun, Mono; Navarrete, Daniel A; Li, Yanyun; Zhang, Mianlei; Nandakumar, Subhiksha; Campos, Carl; Nadeem, Saad; Klimstra, David S; Temple-Oberle, Claire F; Brenn, Thomas; Lipson, Evan J; Schenk, Kara M; Stein, Julie E; Taube, Janis M; White, Michael G; Traweek, Raymond; Wargo, Jennifer A; Kirkwood, John M; Gasmi, Billel; Goff, Stephanie L; Corwin, Alex D; McDonough, Elizabeth; Ginty, Fiona; Callahan, Margaret K; Schietinger, Andrea; Socci, Nicholas D; Mellinghoff, Ingo K; Hollmann, Travis J.

Cancer Immunol Res ; 10(3): 303-313, 2022 03 01.

Artigo em Inglês | MEDLINE | ID: mdl-35013003

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